Iron(iii)-binding of the anticancer agents doxorubicin and vosaroxin-Reference-Cited by-同舟云学术

Iron(iii)-binding of the anticancer agents doxorubicin and vosaroxin

Published:2015 Issue:5 Volume:44 Page:2348-2358
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Mjos Katja Dralle¹²³⁴⁵,Cawthray Jacqueline F.¹²³⁴⁵,Jamieson Gene⁶⁷⁸⁹,Fox Judith A.⁶⁷⁸⁹,Orvig Chris¹²³⁴⁵

Affiliation:

1. Medicinal Inorganic Chemistry Group

2. University of British Columbia

3. Department of Chemistry

4. Vancouver

5. Canada

6. Sunesis Pharmaceuticals

7. Inc.

8. South San Francisco

9. USA

Abstract

The two anticancer agents, doxorubicin and vosaroxin, bind Fe³⁺with comparable strength; however, at physiological pH tris(vosaroxacino)iron(iii) is the dominant species.

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/DT/C4DT02934H

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