Discovery and biological evaluation of dispirocyclic and polycyclic <i>ent</i>-clerodane dimers from <i>Isodon scoparius</i> as novel inhibitors of Toll-like receptor signaling-Reference-Cited by-同舟云学术

Discovery and biological evaluation of dispirocyclic and polycyclic ent-clerodane dimers from Isodon scoparius as novel inhibitors of Toll-like receptor signaling

Published:2022 Issue:15 Volume:9 Page:4023-4033
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Li Xing-Ren¹^ORCID,Chen Li²³,Hu Kun¹,Yan Bing-Chao¹,Du Xue¹,Li Xiao-Nian¹,Sun Han-Dong¹^ORCID,He Shi-Jun²³^ORCID,Puno Pema-Tenzin¹^ORCID

Affiliation:

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China

2. Laboratory of Immunopharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

3. University of Chinese Academy of Sciences, Beijing 100049, China

Abstract

Three novel ent-clerodane dimers (1–3) were discovered. 2 and 3 exhibited remarkable immunosuppressive activity on the activation of purified B cells and significantly abrogated the downstream pathway of TLR7 signaling.

Funder

National Natural Science Foundation of China

Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D2QO00723A

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