Colorimetric visualization of histamine secreted by basophils based on DSP-functionalized gold nanoparticles

Author:

Ling Xiaojing1,Liu Yongxin2,Zhu Danxuan3,An Weizhen2,Geng Jiaying2,Li Lin2ORCID,Yu Changmin2ORCID,Wei Ji-Fu13ORCID

Affiliation:

1. Department of Pharmacy, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, China

2. Key Laboratory of Flexible Electronics (KLOFE), Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing 211800, P. R. China

3. Women & Children Central Laboratory, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210036, China

Abstract

In this study, we developed a novel nanosensor, for the first time, to visually detect endogenous histamine changes in activated basophils by simply coupling dithiobis(succinimidylpropionate) on the surface of AuNPs.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

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