Enterobacter aerogenes ZDY01 inhibits choline-induced atherosclerosis through CDCA-FXR-FGF15 axis-Reference-Cited by-同舟云学术

Enterobacter aerogenes ZDY01 inhibits choline-induced atherosclerosis through CDCA-FXR-FGF15 axis

Published:2021 Issue:20 Volume:12 Page:9932-9946
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Tang Jinghui¹²,Qin Manman¹²,Tang Le¹²,Shan Dan¹²,Zhang Cheng³,Zhang Yifeng¹²,Wei Hua⁴^ORCID,Qiu Liang¹²^ORCID,Yu Jun³

Affiliation:

1. Key Laboratory for Pharmacology and Translational Research of Traditional Chinese Medicine of Nanchang, Centre for Translational Medicine, Jiangxi University of Chinese Medicine, Nanchang 330006, China

2. Jiangxi Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Vascular Remodelling Diseases, China

3. Department of Physiology and Centre for Metabolic Disease Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA

4. State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi, 330047, P. R. China

Abstract

ZDY01 utilized TMA and reduced TMAO level, increased abundance of gut microbiota, accelerated resorption of bile acids into blood by upregulating Asbt and Ostα/β expression, and inactivated FXR-FGF15 axis resulting in increased CYP7A1 expression.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangxi Province

Education Department of Jiangxi Province

Jiangxi University of Traditional Chinese Medicine

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/FO/D1FO02021H

Reference60 articles.