Asymmetric synthesis of spirofuro[2,3-<i>b</i>]azepine-5,3′-indoline derivatives<i>via</i>cycloisomerization/[4 + 3] annulation process under Au/N-heterocyclic carbene relay catalysis-Reference-Cited by-同舟云学术

Asymmetric synthesis of spirofuro[2,3-b]azepine-5,3′-indoline derivativesviacycloisomerization/[4 + 3] annulation process under Au/N-heterocyclic carbene relay catalysis

Published:2023 Issue:13 Volume:10 Page:3347-3352
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

You Mengwei¹,Li Yan¹,Lv Xin¹^ORCID,Shen Guodong²,Xiao Xiao³^ORCID,Zhou Liejin¹^ORCID

Affiliation:

1. Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, College of Chemistry and Material Sciences, Zhejiang Normal University, 688 Yingbin Road, Jinhua 321004, China

2. School of Chemistry and Chemical Engineering, Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, Liaocheng University, Liaocheng 252059, China

3. Institute of Pharmaceutical Science and Technology, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China

Abstract

A variety of enantioenriched spirofuro[2,3-b]azepine-5,3’-indoline derivatives were synthesizedviaAu(I)/chiral NHC relay catalyzed cycloisomerization/asymmetric [4+3] annulation.

Funder

Natural Science Foundation of Zhejiang Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/QO/D3QO00539A

Reference76 articles.

1. Recent Advances in Anticancer Chemotherapeutics based upon Azepine Scaffold

2. Pyrrole, pyrrolidine, pyridine, piperidine, and azepine alkaloids