Novel anilino quinazoline-based EGFR tyrosine kinase inhibitors for treatment of non-small cell lung cancer

Author:

Yang Lili12345,Liu Shanshan12345,Chu Jingjing12345,Miao Shuang12345,Wang Kai12345,Zhang Qingwei12345,Wang Yingyi12345,Xiao Yadi12345,Wu Lina12345,Liu Yang12345,Yu Longjian12345,Yu Caihong12345,Liu Xiang12345,Ke Mingxing12345,Cheng Zhen678910ORCID,Sun Xilin12345ORCID

Affiliation:

1. NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics

2. Molecular Imaging Research Center (MIRC)

3. Harbin Medical University

4. Harbin

5. China

6. Molecular Imaging Program at Stanford (MIPS)

7. Department of Radiology

8. Stanford University School of Medicine

9. Stanford

10. USA

Abstract

The two novel anilino quinazoline-based EGFR-TKIs have promising anti-tumor activity and limited hepatotoxicity, representing excellent candidates for combating the NSCLC.

Funder

National Natural Science Foundation of China

National Basic Research Program of China

Natural Science Foundation of Heilongjiang Province

Harbin Science and Technology Bureau

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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