Dual pH-triggered multistage drug delivery systems based on host–guest interaction-associated polymeric nanogels-Reference-Cited by-同舟云学术

Dual pH-triggered multistage drug delivery systems based on host–guest interaction-associated polymeric nanogels

Published:2014 Issue:58 Volume:50 Page:7824-7827
ISSN:1359-7345
Container-title:Chem. Commun.
language:en
Short-container-title:Chem. Commun.

Author:

Zan Minghui¹²³⁴⁵,Li Junjie¹²³⁴,Luo Shizhong⁵⁶⁷⁸⁹,Ge Zhishen¹²³⁴

Affiliation:

1. CAS Key Laboratory of Soft Matter Chemistry

2. Department of Polymer Science and Engineering

3. University of Science and Technology of China

4. Hefei, China

5. Key Laboratory of Functional Molecular Solids

6. Ministry of Education

7. Anhui Key Laboratory of Molecule-based Materials

8. College of Chemistry and Materials Science

9. Anhui Normal University

Abstract

The multistage polymeric nanogel delivery systems were constructed via host–guest interactions, which showed tumor acidity-triggered disassembly into smaller nanoparticles for deep tissue penetration, high-efficiency cellular uptake, and intracellular endo-lysosomal pH-responsive drug release.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2014/CC/C4CC03120B

Reference28 articles.

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2. Supramolecular Nanodevices: From Design Validation to Theranostic Nanomedicine

3. Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: Concepts and applications

4. Targeted polymeric therapeutic nanoparticles: design, development and clinical translation

5. Polymer conjugates as anticancer nanomedicines

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