Molecular recognition between bacterial phosphorothioate DNA and sulfur-binding domain (SBD): competition between the water cage and chalcogen-hydrophobic packet-Reference-Cited by-同舟云学术

Molecular recognition between bacterial phosphorothioate DNA and sulfur-binding domain (SBD): competition between the water cage and chalcogen-hydrophobic packet

Published:2022 Issue:16 Volume:24 Page:9176-9187
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Li Jiayi¹,Wan Haibo¹,Zhang Haoqing¹,Wang Xiao-Lei¹,Liu Guang¹,Wu Geng¹,He Xinyi¹,Deng Zixin¹,Zhao Yi-Lei¹^ORCID

Affiliation:

1. State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China

Abstract

SBD protein recognizes phosphorothioate DNA via a pull-in/pull-out synergetic mechanism. PT-DNA prefers the chalcogen-bonding (ChB) and hydrophobic interactions inside while normal DNA hydrates better out of the protein.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CP/D2CP00291D

Reference72 articles.

1. DNA phosphorothioation is widespread and quantized in bacterial genomes

2. Assembly of the membrane domain of ATP synthase in human mitochondria