Simply combining fasudil and lipoic acid in a novel multitargeted chemical entity potentially useful in central nervous system disorders-Reference-Cited by-同舟云学术

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Simply combining fasudil and lipoic acid in a novel multitargeted chemical entity potentially useful in central nervous system disorders

Published:2014 Issue:70 Volume:4 Page:37266-37269
ISSN:2046-2069
Container-title:RSC Adv.
language:en
Short-container-title:RSC Adv.

Author:

Chen Meihui¹²³,Liu Qi¹²³⁴⁵,Liu Anmin⁶⁷²⁸,Tan Min¹²³⁹¹⁰,Xie Zhiyong¹²³,Uri Asko¹¹¹²¹³,Chen Ziwei¹²³,Huang Guangye¹²³,Sun Yang¹²³,Ge Hu¹²³,Liu Peiqing¹²³,Li Min¹²³⁴⁵,Li Xingshu¹²³,Wen Shijun¹²³⁴⁵,Pi Rongbiao¹²³

Affiliation:

1. School of Pharmaceutical Sciences

2. Sun Yat-Sen University

3. Guangzhou 510006, China

4. State Key Laboratory of Oncology in South China

5. Sun Yat-sen University Cancer Center

6. Department of Neurosurgery

7. Sun Yat-Sen Memorial Hospital

8. Guangzhou, China

9. Department of Traditional Chinese Medicine Chemistry

10. College of Chinese Materia Madica

11. Institute of Chemistry

12. University of Tartu

13. Tartu 50411, Estonia

Abstract

A novel multifunctional ROCK inhibitor, L-F001, was synthesized and biologically evaluated as a potential drug for the treatment of CNS disorders.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/RA/C4RA07337A

Reference20 articles.

1. Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

2. Kinase inhibitors for CNS diseases: an analysis of the recent patent literature

3. Advances in the development of Rho-associated protein kinase (ROCK) inhibitors

4. Rho kinase inhibitors: a patent review (2012 – 2013)

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1. L‐F001, a multifunctional fasudil–lipoic acid dimer, antagonizes hypoxic–ischemic brain damage by inhibiting the TLR4/MyD88 signaling pathway;Brain and Behavior;2023-10-11

2. Therapeutic Perspectives on ROCK Inhibition for Cerebral Cavernous Malformations;Kinases and Phosphatases;2023-02-23

3. L-F001, a Multifunctional Fasudil-Lipoic Acid Dimer Prevents RSL3-Induced Ferroptosis via Maintaining Iron Homeostasis and Inhibiting JNK in HT22 Cells;Frontiers in Cellular Neuroscience;2022-03-31

4. Emerging targets in drug discovery against neurodegenerative diseases: Control of synapsis disfunction by the RhoA/ROCK pathway;European Journal of Medicinal Chemistry;2021-12

5. Metformin and insulin-resistant related diseases: Emphasis on the role of microRNAs;Biomedicine & Pharmacotherapy;2021-07

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