Dynamic mechanical loading and growth factors influence chondrogenesis of induced pluripotent mesenchymal progenitor cells in a cartilage-mimetic hydrogel

Author:

Aisenbrey Elizabeth A.1234ORCID,Bilousova Ganna56748,Payne Karin86749,Bryant Stephanie J.123410ORCID

Affiliation:

1. Department of Chemical and Biological Engineering

2. University of Colorado at Boulder

3. Boulder

4. USA

5. Department of Dermatology

6. University of Colorado Anschutz Medical Campus

7. Aurora

8. Charles C. Gates Center for Regenerative Medicine

9. Department of Orthopedics

10. Material Science and Engineering Program

Abstract

The chondrogenesis of iPSC-mesenchymal progenitor cells in a cartilage mimetic hydrogel is dependent on the combinatory effects of biophysical cues and exogenous growth factors.

Funder

National Institute of Arthritis and Musculoskeletal and Skin Diseases

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Reference93 articles.

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2. A. K. Dewan , M. A.Gibson , J. H.Elisseeff and M. E.Trice , Evolution of Autologous Chondrocyte Repair and Comparison to Other Cartilage Repair Techniques, https://www.hindawi.com/journals/bmri/2014/272481/

3. Matrix assisted autologous chondrocyte transplantation for cartilage treatment

4. Cell Carriers as the Next Generation of Cell Therapy for Cartilage Repair

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