Citrus auraptene induces drug efflux transporter P-glycoprotein expression in human intestinal cells-Reference-Cited by-同舟云学术

Citrus auraptene induces drug efflux transporter P-glycoprotein expression in human intestinal cells

Published:2020 Issue:6 Volume:11 Page:5017-5023
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Nabekura Tomohiro¹²³⁴⁵^ORCID,Kawasaki Tatsuya¹²³⁴⁵,Kato Yu¹²³⁴⁵,Kawai Kazuyoshi¹²³⁴⁵,Fiorito Serena⁶⁷⁸⁹,Epifano Francesco⁶⁷⁸⁹,Genovese Salvatore⁶⁷⁸⁹,Uwai Yuichi¹²³⁴⁵

Affiliation:

1. Department of Pharmaceutics

2. School of Pharmacy

3. Aichi Gakuin University

4. Chikusa-ku

5. Japan

6. Dipartimento di Farmacia

7. Università “G. d'Annunzio” of Chieti-Pescara

8. 66100 Chieti Scalo

9. Italy

Abstract

Citrus phytochemical auraptene activates the drug efflux transporter P-glycoprotein gene (MDR1) promoter in human intestinal LS174T cells. Auraptene increases protein expression of P-glycoprotein. Auraptene can cause food–drug interactions.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2020/FO/D0FO00315H

Reference34 articles.

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