Structure-based insights into mechanism of endoperoxidase FtmOx1 catalyzed reactions-Reference-Cited by-同舟云学术

Structure-based insights into mechanism of endoperoxidase FtmOx1 catalyzed reactions

Published:2023 Issue:23 Volume:13 Page:6839-6849
ISSN:2044-4753
Container-title:Catalysis Science & Technology
language:en
Short-container-title:Catal. Sci. Technol.

Author:

Wang Fei¹²,Gao Yanqing³,Wang Chunxi¹,Lan Wenxian⁴,Gan JianHua³,Cao Chunyang¹²^ORCID

Affiliation:

1. State Key Laboratory of Bioorganic and Natural Product Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China

2. University of Chinese Academy of Science, No. 19A, Yuquan Road, Shijingshan District, Beijing, 100049, China

3. Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai 200433, China

4. The Core Facility Centre of CAS Center for Excellence in Molecular Plant Sciences, 300 Fengling Road, Shanghai, 200032, China

Abstract

New pathways were suggested for ftmOx1 catalyzed reactions, in which the roles of residues Tyr68, Thr134 and Tyr224 were discussed based on the analysis of the reported structures.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CY/D3CY00092C

Reference14 articles.

1. Natural Endoperoxides as Drug Lead Compounds

2. Hydrogen Donation but not Abstraction by a Tyrosine (Y68) during Endoperoxide Installation by Verruculogen Synthase (FtmOx1)

3. FtmOx1, a non-heme Fe(ii) and α-ketoglutarate-dependent dioxygenase, catalyses the endoperoxide formation of verruculogen in Aspergillus fumigatus

4. Dissecting the Mechanism of the Nonheme Iron Endoperoxidase FtmOx1 Using Substrate Analogues

5. Use of Noncanonical Tyrosine Analogues to Probe Control of Radical Intermediates during Endoperoxide Installation by Verruculogen Synthase (FtmOx1)