Atomic force microscopy-based single-molecule force spectroscopy detects DNA base mismatches-Reference-Cited by-同舟云学术

Atomic force microscopy-based single-molecule force spectroscopy detects DNA base mismatches

Published:2019 Issue:37 Volume:11 Page:17206-17210
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Liu Wenjing¹²³⁴⁵^ORCID,Guo Yourong⁶⁷⁸⁹⁴,Wang Kaizhe¹²³⁴⁵^ORCID,Zhou Xingfei¹⁰¹¹¹²⁴,Wang Ying¹²³⁴¹³,Lü Junhong¹²³⁴¹³,Shao Zhifeng⁶⁷⁸⁹⁴,Hu Jun¹²³⁴¹³^ORCID,Czajkowsky Daniel M.⁶⁷⁸⁹⁴,Li Bin¹²³⁴¹³^ORCID

Affiliation:

1. Shanghai Institute of Applied Physics

2. Chinese Academy of Sciences

3. Shanghai 201800

4. China

5. University of Chinese Academy of Sciences

6. Bio-ID Center

7. School of Biomedical Engineering

8. Shanghai Jiao Tong University

9. Shanghai

10. School of Science

11. Ningbo University

12. Ningbo 315211

13. Zhangjiang Laboratory

Abstract

AFM-based single-molecule-force spectroscopy is limited by low throughput. We introduce addressable DNA origami to study multiple target molecules at once. Target DNAs differing by only a single-base pair mismatch are clearly differentiated.

Funder

National Natural Science Foundation of China

Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2019/NR/C9NR05234H

Reference33 articles.

1. Atomic force microscopy-based characterization and design of biointerfaces

2. Imaging modes of atomic force microscopy for application in molecular and cell biology