Molecular beacons with oxidized bases report on substrate specificity of DNA oxoguanine glycosylases-Reference-Cited by-同舟云学术

Molecular beacons with oxidized bases report on substrate specificity of DNA oxoguanine glycosylases

Published:2022 Issue:15 Volume:13 Page:4295-4302
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Sun Jingjing¹²^ORCID,Antczak Nicole M.¹³^ORCID,Gahlon Hailey L.¹^ORCID,Sturla Shana J.¹^ORCID

Affiliation:

1. Department of Health Sciences and Technology, ETH Zürich, Zürich, 8092, Switzerland

2. Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA

3. Department of Chemistry, Skidmore College, 815 North Broadway, Saratoga Springs, NY 12866, USA

Abstract

A three-color fluorescent molecular beacon assay for rapid profiling of substrate specificity of hOGG1 variants, and for engineering proteins to map genomic modifications.

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D1SC05648D

Reference50 articles.

1. DNA Modification Readers and Writers and Their Interplay

2. Mechanisms of DNA damage, repair, and mutagenesis

3. Genome editing with engineered zinc finger nucleases

4. TALENs: a widely applicable technology for targeted genome editing

5. The CRISPR tool kit for genome editing and beyond

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