Peptide bond cleavage in the presence of Ni-containing particles-Reference-Cited by-同舟云学术

Peptide bond cleavage in the presence of Ni-containing particles

Published:2020-05-01 Issue:5 Volume:12 Page:649-653
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:

Author:

Wezynfeld Nina Ewa¹²^ORCID,Frączyk Tomasz¹³^ORCID,Bonna Arkadiusz⁴^ORCID,Bal Wojciech¹^ORCID

Affiliation:

1. Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5a, 02-106 Warsaw, Poland

2. Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664, Warsaw, Poland

3. Department of Immunology, Transplantology and Internal Medicine, Medical University of Warsaw, Nowogrodzka 59, 02-006 Warsaw, Poland

4. Department of Biochemistry, University of Cambridge, Downing Site, Tennis Court Road, Cambridge CB2 1QW, UK

Abstract

Abstract NiO nanoparticles and non-stoichiometric black NiO were shown to be effective sources of Ni2+ ions causing sequence-selective peptide bond hydrolysis. NiO nanoparticles were as effective in this reaction as their molar equivalent of soluble Ni(ii) salt. These findings highlight the efficacy of delivery of toxic Ni2+ by these environmentally available particles.

Funder

Narodowe Centrum Nauki

European Regional Development Fund

Fundacja na rzecz Nauki Polskiej

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

https://academic.oup.com/metallomics/article-pdf/12/5/649/41702004/d0mt00070a.pdf

Reference36 articles.

1. Metal Allergy—A Review on Exposures, Penetration, Genetics, Prevalence, and Clinical Implications