Cloke–Wilson rearrangement: a unique gateway to access five-membered heterocycles

Author:

Nazeer Usman12,Mushtaq Aqsa1,Zahoor Ameer Fawad1ORCID,Hafeez Freeha13,Shahzadi Irum1,Akhtar Rabia14

Affiliation:

1. Department of Chemistry, Government College University Faisalabad, 38000-Faisalabad, Pakistan

2. Department of Chemistry, University of Houston, 3585 Cullen Boulevard, Texas 77204-5003, USA

3. Department of Chemistry, Riphah International University Faisalabad, 38000-Faisalabad, Pakistan

4. Department of Chemistry, The Superior University Lahore, Faisalabad-Campus, Faisalabad, Pakistan

Abstract

Cloke–Wilson rearrangement is utilized to process cyclopropyl constituting functional groups and results in stable five-membered heterocycles. This rearrangement is also involved in the total synthesis of various natural products.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference149 articles.

1. H.-U.Reissig and Z.Rappoport , The Chemistry of the Cyclopropyl Group , John Wiley & Sons , Chichester , 1987 , pp. 375–443

2. A.de Meijere , Carbocyclic Three- and Four Membered Ring Compounds , in Houben-Weyl Methods of Organic Chemistry , Thieme , Stuttgart , 1997

3. Use of cyclopropanes and their derivatives in organic synthesis

4. J.Salaün , Cyclopropane derivatives and their diverse activities , Small Ring Compounds in Organic Synthesis VI , Springer , 2000 , pp. 1–67

5. Ring strain in cyclopropane, cyclopropene, silacyclopropane, and silacyclopropene

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