Effect of the Sr–Fe layered double hydroxide coating based on the microenvironment response on implant osseointegration in osteoporotic rats

Author:

Liao Chenyu1,He Dongcai2,Yin Kaiwen1,Lin Yuhung1ORCID,Chen Yihan34ORCID,Zhang Ziqiang2,Zhang Jing5ORCID,Luo Hongrong6,Chen Xianchun7,Li Yunfeng1ORCID

Affiliation:

1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Oral & Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China

2. College of Materials Science and Engineering, Sichuan University, No. 24 South Section 1, Yihuan Road, Chengdu, 610065, China

3. Shanghai Institute of Ceramics, Chinese Academy of Science, Research Unit of Nanocatalytic Medicine iSpecific Therapy for Serious Disease, Chinese Academy of Medical Sciences, Shanghai 200050, P.R. China

4. Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, P.R. China

5. College of Architecture and Environment, Sichuan University, Chengdu, Sichuan 610065, China

6. College of Biomedical Engineering, Sichuan University, No. 24 South Section 1, Yihuan Road, Chengdu, 610065, China

7. College of Polymer Science and Engineering, Sichuan University, No. 24 South Section 1, Yihuan Road, Chengdu, 610065, China

Abstract

Sr–Fe LDH coating promotes osteoblastic bone formation and inhibits osteoclastic bone resorption, resulting increased mechanical stability, peripheral bone mass, and osseointegration of implants in osteoporotic rats.

Funder

National Key Research and Development Program of China

Chengdu Municipal Science and Technology Program

Sichuan Province Science and Technology Support Program

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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