Exploring the links between peptoid antibacterial activity and toxicity-Reference-Cited by-同舟云学术

Exploring the links between peptoid antibacterial activity and toxicity

Published:2017 Issue:5 Volume:8 Page:886-896
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Bolt H. L.¹²³⁴,Eggimann G. A.¹²³⁴,Jahoda C. A. B.⁵²⁶⁴,Zuckermann R. N.⁷⁸⁹¹⁰,Sharples G. J.⁵²⁶⁴,Cobb S. L.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Durham University

3. Durham

4. UK

5. School of Biological and Biomedical Sciences

6. Durham DH1 3LE

7. Molecular Foundry

8. Lawrence Berkeley National Laboratory

9. Berkeley

10. USA

Abstract

The cytoxicity profiling of a series of linear peptoids against mammalian cell lines has been carried out and correlated against both antibacterial properties and hydrophobicity.

Funder

Engineering and Physical Sciences Research Council

Swiss National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C6MD00648E

Reference58 articles.

1. The 10 × ‘20 Initiative: Pursuing a Global Commitment to Develop 10 New Antibacterial Drugs by 2020

2. Overview on the recent study of antimicrobial peptides: Origins, functions, relative mechanisms and application

3. Peptide therapeutics: current status and future directions

4. The Future of Peptide-based Drugs

5. Peptides as the next generation of anti-infectives

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