Employing bicontinuous-to-micellar transitions in nanostructure morphology for on-demand photo-oxidation responsive cytosolic delivery and off

Employing bicontinuous-to-micellar transitions in nanostructure morphology for on-demand photo-oxidation responsive cytosolic delivery and off–on cytotoxicity

Published:2020 Issue:9 Volume:12 Page:5332-5340
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Bobbala Sharan¹²³⁴,Allen Sean D.⁵²³⁴,Yi Sijia⁶²³⁴,Vincent Michael¹²³⁴,Frey Molly⁵²³⁴,Karabin Nicholas B.¹²³⁴,Scott Evan A.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Biomedical Engineering

2. Northwestern University

3. Evanston

4. USA

5. Interdepartmental Biological Sciences Program

6. Chemistry of Life Processes Institute

Abstract

PEG-b-PPS bicontinuous nanospheres resist degradation and stably retain payloads within cells. When loaded with a photosensitizing agent, these nanospheres demonstrate off–on inducible photo-responsive release of cytotoxic agents into the cytosol of cells.

Funder

U.S. Department of Energy

Division of Chemical, Bioengineering, Environmental, and Transport Systems

NIH Office of the Director

National Institute of Allergy and Infectious Diseases

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NR/C9NR10921H

Reference24 articles.