An optimized approach in the synthesis of imatinib intermediates and analogues-Reference-Cited by-同舟云学术

An optimized approach in the synthesis of imatinib intermediates and analogues

Published:2016 Issue:66 Volume:6 Page:61458-61467
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Kinigopoulou M.¹²³⁴,Filippidou M.¹²³⁴,Gogou M.¹²³⁴,Giannousi A.¹²³⁴,Fouka P.¹²³⁴,Ntemou N.¹²³⁴,Alivertis D.⁵²³⁴,Georgis C.¹²³⁴,Brentas A.¹²³⁴,Polychronidou V.¹²³⁴,Voulgari P.¹²³⁴,Theodorou V.¹²³⁴,Skobridis K.¹²³⁴

Affiliation:

1. Department of Chemistry

2. University of Ioannina

3. GR-45110 Ioannina

4. Greece

5. Department of Biological Applications and Technology

Abstract

We revisited the classical synthetic procedure for imatinib synthesis providing an improved and optimized approach in the preparation of a series of new imatinib analogues.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA09812F

Reference40 articles.

1. Phenylamino-pyrimidine (PAP) — derivatives: a new class of potent and highly selective PDGF-receptor autophosphorylation inhibitors

2. Potent and selective inhibitors of the Abl-kinase: phenylamino-pyrimidine (PAP) derivatives

3. Phenylamino-Pyrimidine (PAP) Derivatives: A New Class of Potent and Selective Inhibitors of Protein Kinase C (PKC)

4. Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug

5. Activity of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in the Blast Crisis of Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia with the Philadelphia Chromosome

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