Mitochondria-targeted biotin-conjugated BODIPYs for cancer imaging and therapy-Reference-Cited by-同舟云学术

Mitochondria-targeted biotin-conjugated BODIPYs for cancer imaging and therapy

Published:2023 Issue:11 Volume:14 Page:2358-2364
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Dutta Dhiraj¹²^ORCID,Nair Rajshree R.³⁴,Neog Kashmiri¹,Nair S. Asha³,Gogoi Pranjal¹²^ORCID

Affiliation:

1. Applied Organic Chemistry Group, Chemical Science and Technology Division, CSIR-North East Institute of Science and Technology (CSIR-NEIST), Assam, Jorhat-785006, India

2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India

3. Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Trivandrum-695014, Kerala, India

4. Manipal Academy of Higher Education, Manipal-576104, Karnataka, India

Abstract

BODIPY–biotin conjugates are developed for targeted PDT applications. The PSs exhibited suitable photophysical properties and were localized in the mitochondria with excellent photocytotoxicity of up to 18.7 nM in MDA-MB-231 breast cancer cells.

Funder

Department of Biotechnology, Ministry of Science and Technology, India

Department of Science and Technology, Ministry of Science and Technology, India

Rajiv Gandhi Centre for Biotechnology, Department of Biotechnology, Ministry of Science and Technology, India

Indian Council of Medical Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D3MD00347G

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