Small molecule drug conjugates (SMDCs): an emerging strategy for anticancer drug design and discovery

Author:

Patel Tarun Kumar1234,Adhikari Nilanjan56789ORCID,Amin Sk. Abdul56789ORCID,Biswas Swati1234,Jha Tarun56789ORCID,Ghosh Balaram1234ORCID

Affiliation:

1. Epigenetic Research Laboratory, Department of Pharmacy

2. BITS-Pilani

3. Hyderabad

4. India

5. Natural Science Laboratory

6. Division of Medicinal and Pharmaceutical Chemistry

7. Department of Pharmaceutical Technology

8. Jadavpur University

9. Kolkata 700032

Abstract

Mechanisms of how SMDCs work. Small molecule drugs are conjugated with the targeted ligand using pH sensitive linkers which allow the drug molecule to get released at lower lysosomal pH. It helps to accumulate the chemotherapeutic agents to be localized in the tumor environment upon cleaving of the pH-labile bonds.

Funder

Council of Scientific and Industrial Research

Science and Engineering Research Board

University Grants Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

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