Identification and validation of novel microtubule suppressors with an imidazopyridine scaffold through structure-based virtual screening and docking-Reference-Cited by-同舟云学术

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Identification and validation of novel microtubule suppressors with an imidazopyridine scaffold through structure-based virtual screening and docking

Published:2022 Issue:8 Volume:13 Page:929-943
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Elseginy Samia A.¹²,Oliveira A. Sofia F.¹³^ORCID,Shoemark Deborah K.¹^ORCID,Sessions Richard B.¹^ORCID

Affiliation:

1. School of Biochemistry, University of Bristol, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, UK

2. Green Chemistry Department, Chemical Industries Research Division, National Research Centre, 12622, Egypt

3. School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK

Abstract

A fast and effective route to find compounds targeting mitosis. New compounds towards cancer therapeutics.

Funder

Engineering and Physical Sciences Research Council

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/MD/D1MD00392E

Reference54 articles.

1. Microtubule Dynamic Instability and GTP Hydrolysis

2. Tubulin heterogeneity regulates functions and dynamics of microtubules and plays a role in the development of drug resistance in cancer

3. Tubulin modifications and their cellular functions

4. Structural intermediates in microtubule assembly and disassembly: how and why?

5. Antitubulin agents for the treatment of cancer – a medicinal chemistry update

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