New melphalan derivatives for the treatment of retinoblastoma in combination with thermotherapy-Reference-Cited by-同舟云学术

New melphalan derivatives for the treatment of retinoblastoma in combination with thermotherapy

Published:2024 Issue:7 Volume:15 Page:2300-2304
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Zebret Soumaila¹,Hadiji Mouna¹^ORCID,Romano-deGea Jan¹^ORCID,Bornet Aurélien¹,Ortiz Daniel¹,Fadaei-Tirani Farzaneh¹^ORCID,Stathopoulos Christina²,Nowak-Sliwinska Patrycja³⁴,Munier Francis L.²,Dyson Paul J.¹^ORCID

Affiliation:

1. Institute of Chemical Sciences and Engineering (ISIC), École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland

2. Jules-Gonin Eye Hospital, Fondation Asile des Aveugles, University of Lausanne, 1004 Lausanne, Switzerland

3. School of Pharmaceutical Sciences, University of Geneva, 1211 Geneva, Switzerland

4. Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, 1211 Geneva, Switzerland

Abstract

Melphalan, a drug in retinoblastoma treatment, was not designed for combination with focal therapy, but is more active when combined with heat. Incorporating perfluorous chains to the drug rsulted in thermoresponsive and increased cytotoxicity.

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

École Polytechnique Fédérale de Lausanne

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00211C

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