Discovery of a phase-separating small molecule that selectively sequesters tubulin in cells-Reference-Cited by-同舟云学术

Discovery of a phase-separating small molecule that selectively sequesters tubulin in cells

Published:2022 Issue:19 Volume:13 Page:5760-5766
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Ado Genyir¹²,Noda Naotaka¹²,Vu Hue T.¹²,Perron Amelie¹³,Mahapatra Amarjyoti D.¹,Arista Karla Pineda¹²,Yoshimura Hideaki⁴,Packwood Daniel M.³,Ishidate Fumiyoshi³,Sato Shin-ichi¹^ORCID,Ozawa Takeaki⁴^ORCID,Uesugi Motonari¹³⁵^ORCID

Affiliation:

1. Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan

2. Graduate School of Medicine, Kyoto University, Uji, Kyoto 611-0011, Japan

3. Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Kyoto 606-8501, Japan

4. Department of Chemistry, School of Science, The University of Tokyo, Tokyo 113-0033, Japan

5. School of Pharmacy, Fudan University, Shanghai 201203, China

Abstract

A non-peptidic small molecule, R-huezole, phase separates to selectively sequester tubulin proteins to control the cell cycle. Its modular structure provides a framework for designing bioactive molecules to mimic membraneless organelles in cells.

Funder

Japan Society for the Promotion of Science

Kyoto University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D1SC07151C

Reference44 articles.

1. Liquid phase condensation in cell physiology and disease

2. Biomolecular condensates: organizers of cellular biochemistry