Effect of terminal 3′-hydroxymethyl modification of an RNA primer on nonenzymatic primer extension-Reference-Cited by-同舟云学术

Effect of terminal 3′-hydroxymethyl modification of an RNA primer on nonenzymatic primer extension

Published:2016 Issue:80 Volume:52 Page:11905-11907
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Pal Ayan¹²³⁴⁵,Das Rajat S.⁶⁷⁸⁹⁵^ORCID,Zhang Weicheng¹²³⁴⁵,Lang Megan⁶⁷⁸⁹⁵,McLaughlin Larry W.⁶⁷⁸⁹⁵,Szostak Jack W.¹²³⁴⁵^ORCID

Affiliation:

1. Howard Hughes Medical Institute

2. Department of Molecular Biology and Center for Computational and Integrative Biology

3. Massachusetts General Hospital

4. Boston

5. USA

6. Boston College

7. Department of Chemistry

8. Merkert Chemistry Center

9. Chestnut Hill

Abstract

Displacing the hydroxyl nucleophile at the 3′-end of a primer by a single methylene group drastically decreases the rate of primer extension, illustrating the importance of the precise position of the hydroxyl nucleophile.

Funder

Simons Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CC/C6CC06925H

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