Convergent access to mono-fluoroalkene-based peptidomimetics

Author:

Larnaud Florent1,Calata Charlène1,Prunier Anaïs1,Le Guen Clothilde1,Legay Rémi1,Pfund Emmanuel1,Lequeux Thierry1ORCID

Affiliation:

1. Normandie Université, Laboratoire de Chimie Moléculaire et Thioorganique LCMT UMR 6507, ENSICAEN, UNICAEN, CNRS, 6 Bd. du Maréchal Juin, 14050 Caen, France

Abstract

Expeditive racemic synthesis of monofluoroalkene peptide isosteres from aldehydes and substituted aromatic sulfones is reported. The olefination reaction is highly Z-selective from substituted aldehydes to afford transoid peptide mimic precursors.

Funder

Conseil Régional de Haute Normandie

Labex

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Julia–Kocienski Olefination;Reference Module in Chemistry, Molecular Sciences and Chemical Engineering;2024

2. Julia‐Kocienski Olefination in the Synthesis of Trisubstituted Alkenes: Recent Progress;European Journal of Organic Chemistry;2023-08-17

3. Horner–Wadsworth–Emmons reaction as an excellent tool in the synthesis of fluoro-containing biologically important compounds;Organic & Biomolecular Chemistry;2023

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