Local delivery of FTY720 in mesoporous bioactive glass improves bone regeneration by synergistically immunomodulating osteogenesis and osteoclastogenesis

Author:

Liu Lu12345ORCID,Zhao Fujian6784,Chen Xiaoyu12345,Luo Man12345,Yang Zhen12345,Cao Xiaodong12345ORCID,Miao Guohou91011124,Chen Dafu1314151617,Chen Xiaofeng12345

Affiliation:

1. School of Materials Science and Engineering

2. South China University of Technology

3. Guangzhou 510641

4. China

5. National Engineering Research Centre for Tissue Restoration and Reconstruction

6. Stomatological Hospital

7. Southern Medical University

8. Guangzhou 510280

9. Key Laboratory of Oral Medicine

10. Guangzhou Institute of Oral Disease

11. Stomatology Hospital of Guangzhou Medical University

12. Guangzhou 510140

13. Laboratory of Bone Tissue Engineering

14. Beijing Laboratory of Biomedical Materials

15. Beijing Research Institute of Orthopaedics and Traumatology

16. Beijing JiShuiTan Hospital

17. Beijing,100035

Abstract

FTY720@MBGs improve bone regeneration by synergistically immunomodulating osteogenesis and osteoclastogenesis.

Funder

National Natural Science Foundation of China

National Basic Research Program of China

Natural Science Foundation of Guangdong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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