Comprehensive, quantitative bioprocess productivity monitoring using fluorescence EEM spectroscopy and chemometrics
Author:
Affiliation:
1. Nanoscale Biophotonics Laboratory
2. School of Chemistry
3. National University of Ireland
4. Galway, Ireland
5. Bristol-Myers Squibb
6. Process Analytical Sciences
7. Syracuse, USA
Abstract
Using fluorescence excitation-emission matrix spectroscopy and chemometric methods we demonstrate an effective and rapid method for quantitative monitoring of a mammalian cell culture based manufacturing process.
Publisher
Royal Society of Chemistry (RSC)
Subject
Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2014/AN/C4AN00007B
Reference74 articles.
1. T. Chattaway , G. A.Montague and A. J.Morris , in Bioprocessing, Biotechnology , ed. H. J. Rehm and G. Reed , Wiley-VCH Verlag GmbH , Weinheim, Germany , 2nd edn, 2008 , vol. 3 , pp. 319–354
2. Process analytical technology (PAT) for biopharmaceutical products
3. Process analytical technology (PAT) for biopharmaceuticals
4. Large-Scale Transfection of Mammalian Cells for the Fast Production of Recombinant Protein
5. T. Becker , B.Hitzmann , K.Muffler , R.Portner , K. F.Reardon , F.Stahl and R.Ulber , in White Biotechnology , Springer-Verlag Berlin , Berlin , 2007 , vol. 105 , pp. 249–293
Cited by 32 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Process intensification in biopharmaceutical process development and production – an industrial perspective;Physical Sciences Reviews;2023-11-13
2. Excitation–Emission Matrix Fluorescence Spectroscopy Coupled with PARAFAC Modeling for Viability Prediction of Cells;ACS Omega;2023-04-27
3. Assessing the capabilities of 2D fluorescence monitoring in microtiter plates with data-driven modeling for secondary substrate limitation experiments of Hansenula polymorpha;Journal of Biological Engineering;2023-02-13
4. Sensors and Techniques for On-Line Determination of Cell Viability in Bioprocess Monitoring;Bioengineering;2022-12-03
5. Analyzing protein conjugation reactions for antibody‐drug conjugate synthesis using polarized excitation emission matrix spectroscopy;Biotechnology and Bioengineering;2022-09-28
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3