An efficient synthesis of methyl 2-cyano-3,12-dioxoursol-1,9-dien-28-oate (CDDU-methyl ester): analogues, biological activities, and comparison with oleanolic acid derivatives

Author:

Fu Liangfeng123,Lin Qi-Xian123,Liby Karen T.453,Sporn Michael B.453,Gribble Gordon W.123

Affiliation:

1. Department of Chemistry

2. Dartmouth College

3. Hanover, USA

4. Department of Pharmacology and Toxicology

5. Geisel School of Medicine

Abstract

An efficient synthesis of methyl 2-cyano-3,12-dioxoursol-1,9-dien-28-oate (CDDU-methyl ester).

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference35 articles.

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4. New enone derivatives of oleanolic acid and ursolic acid as inhibitors of nitric oxide production in mouse macrophages

5. New Synthetic Triterpenoids: Potent Agents for Prevention and Treatment of Tissue Injury Caused by Inflammatory and Oxidative Stress

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