Retaining the structural integrity of disulfide bonds in diphtheria toxoid carrier protein is crucial for the effectiveness of glycoconjugate vaccine candidates

Author:

Carboni Filippo1,Kitowski Annabel2ORCID,Sorieul Charlotte1ORCID,Veggi Daniele1,Marques Marta C.2,Oldrini Davide1,Balducci Evita1,Brogioni Barbara1,Del Bino Linda1,Corrado Alessio1,Angiolini Francesca1,Dello Iacono Lucia1,Margarit Immaculada1,Romano Maria Rosaria1,Bernardes Gonçalo J. L.23ORCID,Adamo Roberto1ORCID

Affiliation:

1. GSK, Via Fiorentina 10, 53100 Siena, Italy

2. Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal

3. Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK

Abstract

The introduction of glycoconjugate vaccines marks an important point in the fight against various infectious diseases.

Funder

Horizon 2020 Framework Programme

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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