Engineered modular heterocyclic-diamidines for sequence-specific recognition of mixed AT/GC base pairs at the DNA minor groove-Reference-Cited by-同舟云学术

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Engineered modular heterocyclic-diamidines for sequence-specific recognition of mixed AT/GC base pairs at the DNA minor groove

Published:2021 Issue:48 Volume:12 Page:15849-15861
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Guo Pu¹^ORCID,Farahat Abdelbasset A.¹²^ORCID,Paul Ananya¹^ORCID,Boykin David W.¹^ORCID,Wilson W. David¹^ORCID

Affiliation:

1. Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, 50 Decatur St SE, Atlanta, GA 30303, USA

2. Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt

Abstract

This report describes a breakthrough in a project to design minor groove binders to recognize any sequence of DNA.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC04720E

Reference55 articles.

1. DNA minor-groove recognition by small molecules (up to 2000)

2. Recent developments in compounds acting in the DNA minor groove

3. Therapeutic gene regulation using pyrrole–imidazole polyamides

4. Straightforward access to bisbenzamidine DNA binders and their use as versatile adaptors for DNA-promoted processes

5. Minor groove binders as anti-infective agents

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Imidazobenzimidazole fused aza-calix[4]arenes: Synthesis, structure, and Zn2+-selective colorimetric-fluorometric sensor;Chinese Chemical Letters;2023-12

2. X-ray Structure Characterization of the Selective Recognition of AT Base Pair Sequences;ACS Bio & Med Chem Au;2023-04-05

3. Investigation of the effect of structure modification of furamidine on the DNA minor groove binding and antiprotozoal activity;European Journal of Medicinal Chemistry;2023-04

4. Binding to the DNA Minor Groove by Heterocyclic Dications: from AT Specific to GC Recognition Compounds;Current Protocols;2023-04

5. Compound Shape and Substituent Effects in DNA Minor Groove Interactions;Handbook of Chemical Biology of Nucleic Acids;2023

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