Enolate-mediated 1,3-dipolar cycloaddition reaction of β-functionalized ketones with nitrile oxides: direct access to 3,4,5-trisubstituted isoxazoles-Reference-Cited by-同舟云学术

Enolate-mediated 1,3-dipolar cycloaddition reaction of β-functionalized ketones with nitrile oxides: direct access to 3,4,5-trisubstituted isoxazoles

Published:2016 Issue:23 Volume:14 Page:5246-5250
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zhou Xiao¹²³⁴,Xu Xianhong¹²³⁴,Shi Zhenyan¹²³⁴,Liu Kun¹²³⁴,Gao Hua¹²³⁴,Li Wenjun¹²³⁴

Affiliation:

1. School of Pharmacy

2. Qingdao University

3. Qingdao

4. China

Abstract

Enolate-mediated [3 + 2] organocatalytic 1,3-dipolar cycloaddition reactions of β-functionalized ketones with nitrile oxides have been developed. This strategy could generate 3,4,5-trisubstituted isoxazole in high yields and regioselectivities.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB00717A

Reference62 articles.

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