Tuning the steric hindrance of alkylamines: a predictive model of steric editing of planar amines

Author:

Tomasini Michele12ORCID,Voccia Maria12,Caporaso Lucia2,Szostak Michal3,Poater Albert1ORCID

Affiliation:

1. Institut de Química Computacional i Catàlisi, Departament de Química, Universitat de Girona, c/Ma Aurèlia Capmany 69, 17003 Girona, Catalonia, Spain

2. Dipartimento di Chimica e Biologia, Università di Salerno, Via Ponte don Melillo, 84084, Fisciano, Italy

3. Department of Chemistry, Rutgers University, 73 Warren Street, Newark, New Jersey 07102, USA

Abstract

Amines are one of the most prevalent functional groups in chemistry.

Funder

Generalitat de Catalunya

Rutgers, The State University of New Jersey

National Institutes of Health

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Reference109 articles.

1. Science of Synthesis , ed. D. Enders , Thieme , Stuttgart , 2008 , vol. 40a

2. S. A.Lawrence , Amines: Synthesis, Properties and Applications , Cambridge University Press , Cambridge , 1st edn, 2004

3. A.Ricci , Amino Group Chemistry. From Synthesis to the Life Sciences , Wiley-VCH , Weinheim , 1st edn, 2008

4. T. C.Nugent , Chiral Amine Synthesis: Methods, Developments and Applications , Wiley-VCH , Weinheim , 1st edn, 2010

5. The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

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