Single-molecule analysis of genome-wide DNA methylation by fiber FISH coupled with atomic force microscopy-Reference-Cited by-同舟云学术

Single-molecule analysis of genome-wide DNA methylation by fiber FISH coupled with atomic force microscopy

Published:2022 Issue:8 Volume:147 Page:1559-1566
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Bu Lingli¹,Luo Tao¹,Yan Jiangyu¹,Li Guorui¹,Huang Jing¹^ORCID

Affiliation:

1. Institute of Chemical Biology and Nanomedicine (ICBN), State Key Laboratory of Chemo/Biosensing and Chemometrics, School of Biomedical Sciences, Hunan University, Changsha 410082, China

Abstract

A straightforward single-molecule approach was developed for identifying whole-genome DNA methylation through fiber-FISH coupled with AFM. This method has advantages of low DNA input, reproduction, long reads and low cost.

Funder

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/AN/D2AN00216G

Reference46 articles.

1. Epigenetics in human disease and prospects for epigenetic therapy

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5. The DNA methylation landscape in cancer

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