A microfiber scaffold-based 3D in vitro human neuronal culture model of Alzheimer's disease-Reference-Cited by-同舟云学术

A microfiber scaffold-based 3D in vitro human neuronal culture model of Alzheimer's disease

Published:2020 Issue:17 Volume:8 Page:4861-4874
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Ranjan Vivek Damodar¹²³⁴⁵,Qiu Lifeng⁶⁷⁸⁹,Lee Jolene Wei-Ling⁶⁷⁸⁹,Chen Xuelong¹⁰³⁴⁵,Jang Se Eun⁶⁷⁸⁹,Chai Chou¹¹⁷⁸⁹⁵,Lim Kah-Leong¹¹⁷⁸⁹⁵,Tan Eng-King¹²¹³¹⁴¹⁵⁸,Zhang Yilei¹⁶¹⁷¹⁸¹⁹,Huang Wei Min²⁰³⁴⁵,Zeng Li⁶⁷⁸⁹¹²^ORCID

Affiliation:

1. NTU Institute for Health Technologies

2. Interdisciplinary Graduate School

3. Nanyang Technological University

4. Singapore 639798

5. Singapore

6. Neural Stem Cell Research Lab

7. Research Department

8. National Neuroscience Institute

9. Singapore 308433

10. School of Material Science and Engineering

11. Neurodegeneration Laboratory

12. Neuroscience and Behavioral Disorders Program

13. DUKE-NUS Graduate Medical School

14. Singapore 169857

15. Department of Neurology

16. Department of Mechanical Engineering

17. University of Canterbury

18. Christchurch

19. New Zealand

20. School of Mechanical & Aerospace Engineering

Abstract

Highly efficient neurogenic differentiation, maturation as well as spontaneous amplification of pathogenic amyloid-beta 42 (Aβ42) and phospho-tau expression were achieved on interfacing iPSC-derived neurons with 3D PLGA microfiber scaffolds.

Funder

Singapore Heart Foundation

Nanyang Technological University

Ministry of Education - Singapore

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2020/BM/D0BM00833H

Reference70 articles.

1. Alzheimer's Disease and Parkinson's Disease