Evaluation of fluoropyruvate as nucleophile in reactions catalysed by N-acetyl neuraminic acid lyase variants: scope, limitations and stereoselectivity-Reference-Cited by-同舟云学术

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Evaluation of fluoropyruvate as nucleophile in reactions catalysed by N-acetyl neuraminic acid lyase variants: scope, limitations and stereoselectivity

Published:2016 Issue:1 Volume:14 Page:105-112
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Stockwell Jennifer¹²³⁴⁵,Daniels Adam D.⁵²³⁴⁶,Windle Claire L.⁵²³⁴⁶,Harman Thomas A.¹²³⁴⁵,Woodhall Thomas¹²³⁴⁵,Lebl Tomas¹⁷⁸⁴,Trinh Chi H.⁵²³⁴⁶,Mulholland Keith⁹¹⁰¹¹⁴,Pearson Arwen R.⁵²³⁴⁶,Berry Alan⁵²³⁴⁶,Nelson Adam¹²³⁴⁵

Affiliation:

1. School of Chemistry

2. University of Leeds

3. Leeds

4. UK

5. Astbury Centre for Structural Molecular Biology

6. School of Molecular and Cellular Biology

7. University of St Andrews

8. St Andrews

9. Chemical Development

10. AstraZeneca

11. Cheshire

Abstract

The stereochemical course of aldolase-catalysed reaction between fluoropyruvate and aldehydes is described.

Funder

Engineering and Physical Sciences Research Council

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C5OB02037A

Reference32 articles.

1. Important fluorinated drugs in experimental and clinical use

2. Fluorine in Pharmaceuticals: Looking Beyond Intuition

3. The Many Roles for Fluorine in Medicinal Chemistry

4. Applications of Fluorine in Medicinal Chemistry

5. Fluorine in health care: Organofluorine containing blockbuster drugs

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2. Biocatalytic Asymmetric Construction of Secondary and Tertiary Fluorides from β‐Fluoro‐α‐Ketoacids**;Angewandte Chemie International Edition;2022-03-24

3. Recent Advances in the Substrate Selectivity of Aldolases;ACS Catalysis;2021-12-27

4. Recent trends in the stereoselective synthesis of (poly)-substituted 2-oxo acids by biocatalyzed aldol reaction;Current Opinion in Green and Sustainable Chemistry;2021-08

5. Selective Nuclear Magnetic Resonance Experiments for Sign-Sensitive Determination of Heteronuclear Couplings: Expanding the Analysis of Crude Reaction Mixtures;Analytical Chemistry;2020-09-14

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