Synthesis and biological evaluation of indazole derivatives as anti-cancer agents

Author:

Wei Wei12345,Liu Zhihao12345,Wu Xiuli12345,Gan Cailing12345,Su Xingping12345,Liu Hongyao12345,Que Hanyun12345,Zhang Qianyu67845,Xue Qiang12345,Yue Lin12345,Yu Luoting12345ORCID,Ye Tinghong12345ORCID

Affiliation:

1. Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer

2. State Key Laboratory of Biotherapy and Cancer Center

3. West China Hospital

4. Sichuan University

5. Chengdu

6. Research Center for Public Health & Preventive Medicine

7. West China School of Public Health & Healthy Food Evaluation Research Center

8. West China Fourth Hospital

Abstract

One of the synthesized indazole derivatives, 2f, displayed inhibitory activities against proliferation, migration and invasion of breast cancer cell line 4T1, with the potential of inducing cell apoptosis, and suppressing tumor growth in vivo.

Funder

National Natural Science Foundation of China

West China Hospital, Sichuan University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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