Cationic poly(amino acid) surface functionalized manganese nanoparticles for nitric oxide-based immunotherapy and magnetic resonance imaging-Reference-Cited by-同舟云学术

Cationic poly(amino acid) surface functionalized manganese nanoparticles for nitric oxide-based immunotherapy and magnetic resonance imaging

Published:2022 Issue:28 Volume:10 Page:5402-5409
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Lim Jong-Woo¹,Son Hye Young²³,Huh Yong-Min²³⁴,Haam Seungjoo¹^ORCID

Affiliation:

1. Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 03722, Republic of Korea

2. Department of Radiology, College of Medicine, Yonsei University, Seoul 03722, Republic of Korea

3. YUHS-KRIBB Medical Convergence Research Institute, Seoul 03722, Republic of Korea

4. Department of Biochemistry & Molecular Biology, College of Medicine, Yonsei University, Seoul 03722, Republic of Korea

Abstract

Poly(l-arginine) and hyaluronic acid modified MnO2 nanoparticles (hpMNPs) reprogrammed M2 macrophages to M1 secreting high level of pro-inflammatory cytokines and nitric oxide, leading to apoptosis of tumor cells.

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2022/TB/D2TB00794K

Reference35 articles.

1. Innate and adaptive immune cells in the tumor microenvironment

2. The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications

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5. TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy

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