Quercetin ameliorates neuroinflammatory and neurodegenerative biomarkers in the brain and improves neurobehavioral parameters in a repeated intranasal amyloid-beta exposed model of Alzheimer's disease-Reference-Cited by-同舟云学术

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Quercetin ameliorates neuroinflammatory and neurodegenerative biomarkers in the brain and improves neurobehavioral parameters in a repeated intranasal amyloid-beta exposed model of Alzheimer's disease

Published:2024 Issue:17 Volume:15 Page:8712-8728
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Lasure Vaibhav Uttamrao¹,Singh Gautam Avtar¹,Singh Rakesh Kumar¹^ORCID

Affiliation:

1. Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER) – Raebareli, Transit Campus, Bijnour-Sisendi Road, Sarojini Nagar, Lucknow-226002, Uttar Pradesh, India

Abstract

Quercetin exerted antioxidant and anti-inflammatory properties to protect brain neuronal health. It also ameliorated Aβ deposition, and regulated APP, BACE-1 and tau hyperphosphorylation in brain, and improved neurobehavioral cognitive parameters.

Funder

Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, India

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/FO/D4FO02602K

Reference75 articles.

1. Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

2. Amyloid Beta in Aging and Alzheimer’s Disease

3. The Amyloid-β Pathway in Alzheimer’s Disease

4. Mechanistic insights and perspectives involved in neuroprotective action of quercetin

5. Quercetin in Animal Models of Alzheimer’s Disease: A Systematic Review of Preclinical Studies

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