Antimicrobial polymer-siRNA polyplexes as a dual-mode platform for the treatment of wound biofilm infections-Reference-Cited by-同舟云学术

Antimicrobial polymer-siRNA polyplexes as a dual-mode platform for the treatment of wound biofilm infections

Published:2023 Issue:12 Volume:10 Page:5500-5507
ISSN:2051-6347
Container-title:Materials Horizons
language:en
Short-container-title:Mater. Horiz.

Author:

Jeon Taewon¹,Makabenta Jessa Marie V.²,Park Jungmi²^ORCID,Nabawy Ahmed²^ORCID,Cicek Yagiz Anil²,Mirza Sarah S.³,Welton Janelle³,Hassan Muhammad Aamir²,Huang Rui²,Mager Jesse³,Rotello Vincent M.¹²^ORCID

Affiliation:

1. Molecular and Cellular Biology Graduate Program, University of Massachusetts Amherst, 230 Stockbridge Road, Amherst, Massachusetts, 01003, USA

2. Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts, 01003, USA

3. Department of Veterinary and Animal Sciences, University of Massachusetts Amherst, 661 N Pleasant Street, Amherst, Massachusetts, 01003, USA

Abstract

Dual therapeutics use cationic polymers to kill bacteria and deliver siRNA to macrophages to decrease inflammation and enhance wound healing.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrical and Electronic Engineering,Process Chemistry and Technology,Mechanics of Materials,General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MH/D3MH01108A

Reference35 articles.

1. Human Wounds and Its Burden: An Updated Compendium of Estimates

2. Chronic wound biofilms

3. Pharmaceutical strategies for the treatment of bacterial biofilms in chronic wounds

4. The biofilm matrix

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