Light-initiated 1,3-dipolar cycloaddition between dehydroalanines and tetrazoles: application to late-stage peptide and protein modifications-Reference-Cited by-同舟云学术

Light-initiated 1,3-dipolar cycloaddition between dehydroalanines and tetrazoles: application to late-stage peptide and protein modifications

Published:2023 Issue:35 Volume:14 Page:9418-9426
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Zhang Mengqian¹^ORCID,He Peiyang¹^ORCID,Li Yanmei¹²³^ORCID

Affiliation:

1. Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China

2. Beijing Institute for Brain Disorders, Beijing 100069, P. R. China

3. Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, P. R. China

Abstract

An efficient strategy for dehydroalanine cycloaddition modification was reported, which enables rapid generation of fluorescent pyrazoline-modified peptides and proteins under mild, non-catalytic reaction conditions.

Funder

National Key Research and Development Program of China

Natural Science Foundation of Shandong Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC02818F

Reference51 articles.

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4. Chemical modifications of tryptophan residues in peptides and proteins

5. Chemical modification of proteins – challenges and trends at the start of the 2020s

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