Guanidinoneomycin-maleimide molecular transporter: synthesis, chemistry and cellular uptake-Reference-Cited by-同舟云学术

Guanidinoneomycin-maleimide molecular transporter: synthesis, chemistry and cellular uptake

Published:2021 Issue:29 Volume:19 Page:6513-6520
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Hadidi Kaivin¹²³⁴⁵,Bellucci Maria Cristina⁶⁷⁸⁹¹⁰,Dall'Angelo Sergio¹¹¹²¹³¹⁴^ORCID,Leeson-Payne Alasdair¹⁵¹²¹⁶¹⁴,Rochford Justin J.¹⁵¹²¹⁶¹⁴,Esko Jeffery D.¹⁷²³⁴⁵,Tor Yitzhak¹²³⁴⁵^ORCID,Volonterio Alessandro¹⁸¹⁹²⁰²¹¹⁰^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry

2. University of California

3. San Diego

4. La Jolla

5. USA

6. Department of Food

7. Environmental and Nutritional Sciences

8. Università degli Studi di Milano

9. 20133 Milano

10. Italy

11. Institute of Medical Sciences

12. University of Aberdeen

13. AB25 2ZD Aberdeen

14. UK

15. The Rowett Institute and Aberdeen Cardiovascular and Diabetes Centre

16. Aberdeen AB25 2ZD

17. Department of Cellular and Molecular Medicine

18. Department of Chemistry

19. Material and Chemical Engineer “Giulio Natta”

20. Politecnico di Milano

21. 20131 Milano

Abstract

Guanidinoneomycin-maleimide is a stable, easy to handle molecular transporter which allows for thiol-maleimide bioconjugation and promotes cellular uptake of high molecular weight cargos at low nanomolar concentrations.

Funder

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB01101D

Reference60 articles.

1. Improving cellular uptake of therapeutic entities through interaction with components of cell membrane

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