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The evolution of small molecule enzyme activators

  • Published:2023 Issue:11 Volume:14 Page:2206-2230
  • ISSN:2632-8682
  • Container-title:RSC Medicinal Chemistry
  • language:en
  • Short-container-title:RSC Med. Chem.

Author:

Dow Louise F.1,Case Alfie M.1,Paustian Megan P.1,Pinkerton Braeden R.1,Simeon Princess1,Trippier Paul C.123ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68106, USA

2. Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68106, USA

3. UNMC Center for Drug Discovery, University of Nebraska Medical Center, Omaha, NE 68106, USA

Abstract

Enzyme activation is an emerging mechanism of action for new therapeutic discovery, its evolution and application is reviewed herein.

Funder

National Institute of Neurological Disorders and Stroke

Congressionally Directed Medical Research Programs

Division of Cancer Prevention, National Cancer Institute

Eunice Kennedy Shriver National Institute of Child Health and Human Development

National Institute on Aging

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

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