Ultrafast synthesis of 2-(benzhydrylthio)benzo[d]oxazole, an antimalarial drug, via an unstable lithium thiolate intermediate in a capillary microreactor-Reference-Cited by-同舟云学术

Ultrafast synthesis of 2-(benzhydrylthio)benzo[d]oxazole, an antimalarial drug, via an unstable lithium thiolate intermediate in a capillary microreactor

Published:2020 Issue:5 Volume:5 Page:849-852
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Ramanjaneyulu Bandaru T.¹²³⁴⁵,Vidyacharan Shinde¹²³⁴⁵,Ahn Gwang-Noh¹²³⁴⁵^ORCID,Kim Dong-Pyo¹²³⁴⁵^ORCID

Affiliation:

1. Center of Intelligent Microprocess of Pharmaceutical Synthesis

2. Department of Chemical Engineering

3. Pohang University of Science and Technology (POSTECH)

4. Pohang

5. 37673 Korea

Abstract

We present an ultrafast approach for the synthesis of 2-(benzhydrylthio)benzo[d]oxazole, an antimalarial drug, in 75% yield from benzo[d]oxazole-2-thiol and benzhydryl bromide via an unstable lithium thiolate intermediate in the presence of n-BuLi.

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RE/D0RE00038H

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