Hydroxycinnamic acid as a novel scaffold for the development of cyclooxygenase-2 inhibitors-Reference-Cited by-同舟云学术

Hydroxycinnamic acid as a novel scaffold for the development of cyclooxygenase-2 inhibitors

Published:2015 Issue:72 Volume:5 Page:58902-58911
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Silva T.¹²³⁴⁵,Borges F.¹²³⁴⁵,Edraki N.⁶⁷⁸⁹,Alizadeh M.⁶⁷⁸⁹,Miri R.⁶⁷⁸⁹,Saso L.¹⁰¹¹¹²¹³,Firuzi O.⁶⁷⁸⁹

Affiliation:

1. CIQ/Department of Chemistry and Biochemistry

2. Faculty of Sciences

3. University of Porto

4. 4169-007 Porto

5. Portugal

6. Medicinal and Natural Products Chemistry Research Center

7. Shiraz University of Medical Sciences

8. Shiraz

9. Iran

10. Department of Physiology and Pharmacology Vittorio Erspamer

11. Sapienza University of Rome

12. Rome

13. Italy

Abstract

The most active hydroxycinnamic acid derivative, caffeic acid diethyl ester (CA-DE), demonstrated 88.5/30.5% inhibition at 100/20 μM against COX-2 and negligible COX-1 inhibitory effect. CA-DE showed preferred interactions with COX-2 active site.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA08692B

Reference47 articles.

1. Cyclooxygenase inhibitors – current status and future prospects

2. Why there are two cyclooxygenase isozymes

3. Prostaglandins and Inflammation

4. Biology of Cox-2: An Application in Cancer Therapeutics

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