Straightforward synthesis of bench-stable heteroatom-centered difluoromethylated entities via controlled nucleophilic transfer from activated TMSCHF2-Reference-Cited by-同舟云学术

Straightforward synthesis of bench-stable heteroatom-centered difluoromethylated entities via controlled nucleophilic transfer from activated TMSCHF₂

Published:2022 Issue:38 Volume:58 Page:5761-5764
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Miele Margherita¹,Castoldi Laura²,Simeone Xenia¹,Holzer Wolfgang¹,Pace Vittorio¹³^ORCID

Affiliation:

1. University of Vienna - Department of Pharmaceutical Chemistry, Althanstrasse, 14 1090 Vienna, Austria

2. University of Milano - Department of Pharmaceutical Sciences, Via Golgi 19, 20133 Milano, Italy

3. University of Torino - Department of Chemistry, Via Giuria 7, 10125 Torino, Italy

Abstract

The commercially available difluoromethyltrimethylsilane acts as a valuable difluoromethylating agent for heteroatom-based electrophiles. Upon activation with an alkoxide, a nucleophilic displacement furnishes the corresponding bench-stable analogues.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC00886F

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