A new synthesis and preliminary evaluation of some analogues of mecamylamine – a compound with anti-addiction properties-Reference-Cited by-同舟云学术

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A new synthesis and preliminary evaluation of some analogues of mecamylamine – a compound with anti-addiction properties

Published:2016 Issue:46 Volume:14 Page:10787-10798
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Mangan David¹²³⁴⁵,McNabola Neasa¹²³⁴⁵,Clark Emily H.⁶⁷⁸⁹,Bermudez Isabel¹⁰¹¹¹²⁹,Wonnacott Susan⁶⁷⁸⁹,Southern J. Mike¹²³⁴⁵

Affiliation:

1. Trinity Biomedical Sciences Institute

2. School of Chemistry

3. The University of Dublin

4. Trinity College

5. Dublin 2

6. Department of Biology & Biochemistry

7. University of Bath

8. Bath BA2 7AY

9. UK

10. School of Life Sciences

11. Oxford Brookes University

12. Oxford OX3 0BP

Abstract

A new synthesis of mecamylamine allowed the preparation of analogues to probe biological activity.

Funder

Irish Research Council for Science, Engineering and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB01974A

Reference45 articles.

1. American Psychiatric Association, Substance and related addictive disorders, in Diagnostic and Statistics Manual of Mental Disorders, American Psychiatric Association, 5th edn, 2013, 10.1176/appi.books.9780890425596.dsm16

2. Hypersensitivity to Reward in Problem Gamblers

3. Is there a common molecular pathway for addiction?

4. Dopamine and drug addiction: the nucleus accumbens shell connection

5. http://www.who.int/mediacentre/factsheets/fs339/en/

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1. Regioselective hydroamination of unactivated olefins with diazirines as a diversifiable nitrogen source;Nature Communications;2024-07-18

2. Kinetic Resolution of Alkylidene Norcamphors via a Ligand-Controlled Umpolung-Type 1,3-Dipolar Cycloaddition;iScience;2019-01

3. Ethyl-for-methyl substitution enhances the subtype specificity of mecamylamine analogues;Organic & Biomolecular Chemistry;2019

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