Activation of the cGAS-STING pathway by a mitochondrial DNA-targeted emissive rhodium(<scp>iii</scp>) metallointercalator-Reference-Cited by-同舟云学术

Activation of the cGAS-STING pathway by a mitochondrial DNA-targeted emissive rhodium(iii) metallointercalator

Published:2023 Issue:25 Volume:14 Page:6890-6903
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Zheng Yue¹^ORCID,Chen Xiao-Xiao¹,Zhang Dong-Yang¹,Wang Wen-Jin¹,Peng Kun¹^ORCID,Li Zhi-Yuan¹,Mao Zong-Wan¹^ORCID,Tan Cai-Ping¹^ORCID

Affiliation:

1. MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, State Key Laboratory of Oncology in South China, Sun Yat-Sen University, Guangzhou 510006, P. R. China

Abstract

A highly emissive mtDNA intercalator Rh-Mito induces damaged mtDNA release to activate the cGAS-STING pathway and triggers mitochondrial retrograde by perturbing metabolites involved in DNA methylation, further evoking an antitumor immune response.

Funder

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC01737K

Reference72 articles.

1. STING: infection, inflammation and cancer