The muscarinic effect of anhydroecgonine methyl ester, a crack cocaine pyrolysis product, impairs melatonin synthesis in the rat pineal gland-Reference-Cited by-同舟云学术

The muscarinic effect of anhydroecgonine methyl ester, a crack cocaine pyrolysis product, impairs melatonin synthesis in the rat pineal gland

Published:2017 Issue:4 Volume:6 Page:420-431
ISSN:2045-452X
Container-title:Toxicology Research
language:en
Short-container-title:Toxicol. Res.

Author:

Medeiros de Mesquita Lívia Silva¹²³⁴⁵,Garcia Raphael Caio Tamborelli⁶⁷⁸³⁴,Amaral Fernanda Gaspar⁵⁹⁸³⁴,Peres Rafael⁵⁹⁸³⁴,Wood Simone Miller⁶⁷⁸³⁴,Lucena RodrigoVincenzo de Luca¹²³⁴,Frare Eduardo Osório¹²³⁴,Abrahão Mariana Vieira¹²³⁴,Marcourakis Tania⁶⁷⁸³⁴,Cipolla-Neto José⁵⁹⁸³⁴,Afeche Solange Castro¹²³⁴^ORCID

Affiliation:

1. Laboratory of Pharmacology

2. Butantan Institute

3. São Paulo

4. Brazil

5. Department of Physiology and Biophysics

6. Department of Clinical and Toxicological Analysis

7. School of Pharmaceutical Sciences

8. University of São Paulo

9. Institute of Biomedical Sciences

Abstract

AEME impaired melatonin synthesis bothin vivoand in vitro and this effect seems to be mediated by muscarinic receptors and [Ca²⁺]i elevation.